Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …
International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems
The aim of this study was to ascertain the level of concordance among gastrointestinal
pathologists for regression grading in rectal cancers treated with neoadjuvant …
pathologists for regression grading in rectal cancers treated with neoadjuvant …
Reporting trends of right-sided hyperplastic and sessile serrated polyps in a large teaching hospital over a 4-year period (2009–2012)
Aim An audit of serrated polyps diagnosed over a 4-year period: 2009 to 2012 was
undertaken to ascertain the reporting trends of sessile serrated polyps (SSP). Methods All …
undertaken to ascertain the reporting trends of sessile serrated polyps (SSP). Methods All …
[HTML][HTML] Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
N Camacho, P Van Loo, S Edwards, JD Kay… - PLoS …, 2017 - journals.plos.org
A variety of models have been proposed to explain regions of recurrent somatic copy
number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA …
number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA …
[HTML][HTML] Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures
Genetic signatures have added a molecular dimension to prognostics and therapeutic
decision-making. However, tumour heterogeneity in prostate cancer and current sampling …
decision-making. However, tumour heterogeneity in prostate cancer and current sampling …
The handling and sampling of radical prostatectomy specimens for reporting and research: the Oxford approach
PS Gill, ISD Roberts, L Browning, R Perera… - Journal of clinical …, 2012 - jcp.bmj.com
This article reviews previously described methods of fresh tissue sampling from radical
prostatectomy specimens for research and describes a method used in Oxford which is …
prostatectomy specimens for research and describes a method used in Oxford which is …
[HTML][HTML] Proximal colon cancer and serrated adenomas–hunting the missing 10%
P Gill, H Rafferty, D Munday, A Bailey, LM Wang… - Clinical …, 2013 - ncbi.nlm.nih.gov
There is a 10% shortfall in the number of proximal colorectal cancer cases detected by the
UK Bowel Cancer Screening Programme and the actual number of UK-registered proximal …
UK Bowel Cancer Screening Programme and the actual number of UK-registered proximal …
Role of chemokines, neuronal projections, and the blood-brain barrier in the enhancement of cerebral EAE following focal brain damage
D Sun, M Tani, TA Newman, K Krivacic… - … of Neuropathology & …, 2000 - academic.oup.com
The role of focal brain damage as a trigger for autoimmune inflammation in multiple
sclerosis (MS) is unclear. In this study we examine mechanisms by which experimental …
sclerosis (MS) is unclear. In this study we examine mechanisms by which experimental …
A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation
To ascertain the approach and degree of consensus of pathologists in the handling and
regression grading of colorectal cancer resection specimens treated with neoadjuvant …
regression grading of colorectal cancer resection specimens treated with neoadjuvant …
A pathologist's survey on the reporting of sessile serrated adenomas/polyps
Aim The purpose of this survey was to ascertain reporting habits of pathologists towards
sessile serrated adenomas/polyps (SSA/P). Methods A questionnaire designed to highlight …
sessile serrated adenomas/polyps (SSA/P). Methods A questionnaire designed to highlight …