(First of Two Parts) THE prostaglandins and thromboxane A2 are biologically active
metabolites of arachidonic acid. 1, 2 Their actions and the pharmacologic agents that …

Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene,
glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic …

The frequency of fungal infections is increasing. Amphotericin B remains the antifungal drug
of choice for most systemic infections, but a limiting factor for its use is the development of …

Interethnic differences in debrisoquin and mephenytoin hydroxylation have been compared
between normal white (n= 183) and Japanese (n= 100) subjects with the 8‐hour urinary …

Objectives To determine whether the probe drugs caffeine, chlorzoxazone, dapsone,
debrisoquin (INN, debrisoquine), and mephenytoin can be simultaneously administered as …

Background The liver plays a significant role in drug metabolism; thus it would be expected
that liver disease may have a detrimental effect on the activity of cytochrome P450 (CYP) …

We investigated prostacyclin (PGI 2) biosynthesis during pregnancy by measuring urinary
excretion of 2, 3-dinor-6-keto-prostaglandin F 1α (dinor) and 15-keto-13, 14-dihydro-2, 3 …

Abstract BACKGROUND: Intrahepatic arterial yttrium 90 (90Y) microspheres have been
proposed as a less toxic, less invasive therapeutic option to transhepatic arterial …

Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic
amines, which are present in tobacco and are potent bladder carcinogens, is compromised …

Background and objective The activity of cytochrome P450 (CYP) enzymes, which
determine the rate of elimination of lipid‐soluble drugs, demonstrates considerable …