The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …

OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …

The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Objective Functional suitability and phenotypic stability of ectopic transplants are crucial
factors in the clinical application of mesenchymal stem cells (MSCs) for articular cartilage …

Densely fossiliferous deposits are receiving increasing attention for their yield of
paleobiologic data and their usefulness in sedimentology and stratigraphy. This trend has …

Congenital nephrotic syndrome (CNS) is clinically and genetically heterogeneous, with
mutations in WT1, NPHS1 and NPHS2 accounting for part of cases. We recently delineated …

Objective Osteoarthritic (OA) cartilage destruction depends on collagen‐and aggrecan‐
degrading proteases such as collagenases (MMP‐1 and MMP‐13), stromelysin (MMP‐3) …

Connective tissues tend to heal naturally and successfully only if the injury is minor. If the
damage is more severe, then a good functional result can be achieved only if Nature is …

Storm-induced high energy events dominate stratification phenomena in Upper Muschelkalk
epicontinental carbonates. Within storm beds (tempestites) diagnostic sedimentological and …

Objective Despite many research efforts in recent decades, the major pathogenetic
mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage …