[HTML][HTML] Iron overload in sickle cell disease

R Raghupathy, D Manwani, JA Little - Advances in hematology, 2010 - hindawi.com
In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells
capable of forming sickle hemoglobin polymer. This limits hemolysis and the endothelial …

Epstein-Barr virus as a paradigm in nasopharyngeal cancer: from lab to clinic

R Raghupathy, EP Hui, ATC Chan - American Society of Clinical …, 2014 - ascopubs.org
Nasopharyngeal carcinoma (NPC) of the undifferentiated subtype remains endemic in
southern China, with a peak incidence in this region approaching 30 cases per 100,000 …

[HTML][HTML] Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases

WKJ Lam, P Jiang, KCA Chan, W Peng… - Nature …, 2019 - nature.com
Epstein-Barr virus (EBV) is associated with a number of diseases, including malignancies.
Currently, it is not known whether patients with different EBV-associated diseases have …

Promising therapies in sickle cell disease

R Raghupathy, HH Billett - Cardiovascular & Haematological …, 2009 - ingentaconnect.com
Despite the fact that sickle cell anemia was one of the first diseases to have a demonstrated
genetic etiology, to date there is still only one approved therapy for this disease. Recent …

FNDC3B is another novel partner fused to RARA in the t (3; 17)(q26; q21) variant of acute promyelocytic leukemia

CK Cheng, AZ Wang, THY Wong… - Blood, The Journal …, 2017 - ashpublications.org
10. Kovacs G, Robrecht S, Fink AM, et al. Minimal residual disease assessment improves
prediction of outcome in patients with chronic lymphocytic leukemia (CLL) who achieve …

[HTML][HTML] Acute promyelocytic leukaemia: population-based study of epidemiology and outcome with ATRA and oral-ATO from 1991 to 2021

H Gill, R Raghupathy, CYY Lee, Y Yung, HT Chu… - BMC cancer, 2023 - Springer
Background The epidemiology and treatment of acute promyelocytic leukaemia (APL) are
changing. We have incorporated oral arsenic trioxide (oral-ATO) into induction/maintenance …

Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules

MJL Ma, H Zhang, P Jiang, STK Sin, WKJ Lam… - Clinical …, 2019 - academic.oup.com
Abstract BACKGROUND Cellular mitochondrial DNA (mtDNA) is organized as circular,
covalently closed and double-stranded DNA. Studies have demonstrated the presence of …

[HTML][HTML] SPINK2 protein expression is an independent adverse prognostic marker in AML and is potentially implicated in the regulation of ferroptosis and immune …

HA Pitts, CK Cheng, JS Cheung, MKH Sun… - International Journal of …, 2023 - mdpi.com
There is an urgent need for the identification as well as clinicopathological and functional
characterization of potent prognostic biomarkers and therapeutic targets in acute myeloid …

The OnControl Bone Marrow Biopsy Technique Is Superior to the Standard Manual Technique for Hematologists-In-Training: A Prospective, Rrandomized …

LJ Reed, R Raghupathy, M Strakhan, TE Philbeck… - Hematology …, 2011 - mdpi.com
The purpose of this study was to compare a novel bone marrow device with the standard
marrow needle in a prospective, randomized study in a teaching hospital employing …

Epidemiology and outcomes of acute promyelocytic leukaemia in the era of all-trans retinoic acid (ATRA) chemotherapy and arsenic trioxide plus ATRA: a …

H Gill, R Raghupathy, M Ni, X Xiao, F Flores… - The Lancet …, 2022 - thelancet.com
Background Acute promyelocytic leukaemia (APL) results from the reciprocal chromosomal
translocation t (15; 17)(q24; 21)(PML–RARA gene fusion). We have formulated an oral …