[HTML][HTML] HER2 expression status in diverse cancers: review of results from 37,992 patients
M Yan, M Schwaederle, D Arguello, SZ Millis… - Cancer and Metastasis …, 2015 - Springer
Human epidermal growth factor receptor 2 (HER2) amplification/overexpression is an
effective therapeutic target in breast and gastric cancer. Although HER2 positivity has been …
effective therapeutic target in breast and gastric cancer. Although HER2 positivity has been …
[HTML][HTML] High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine
Z Gatalica, S Vranic, J Xiu, J Swensen, S Reddy - Familial cancer, 2016 - Springer
Approximately 15% of colorectal carcinomas (CRC) display high level microsatellite
instability (MSI-H) due to either a germline mutation in one of the genes responsible for DNA …
instability (MSI-H) due to either a germline mutation in one of the genes responsible for DNA …
[HTML][HTML] Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: a new clinical paradigm in the treatment of triple-negative breast …
FS Cyprian, S Akhtar, Z Gatalica… - Bosnian Journal of Basic …, 2019 - ncbi.nlm.nih.gov
The treatment of several solid and hematologic malignancies with immune checkpoint
inhibitors (against programmed death receptor-1/ligand-1 [PD-1/PD-L1]) has dramatically …
inhibitors (against programmed death receptor-1/ligand-1 [PD-1/PD-L1]) has dramatically …
Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type
Z Gatalica, C Snyder, T Maney, A Ghazalpour… - … , biomarkers & prevention, 2014 - AACR
Cancer cells expressing PD-1 ligands (PD-L1/PD-L2) inhibit immune-modulatory T-cell
activation facilitating disease progression. Preliminary clinical trials exploring interruption of …
activation facilitating disease progression. Preliminary clinical trials exploring interruption of …
[HTML][HTML] Molecular characterization of cancers with NTRK gene fusions
Z Gatalica, J Xiu, J Swensen, S Vranic - Modern Pathology, 2019 - Elsevier
Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients
with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently …
with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently …
Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population
Y Saitoh, I Waxman, AB West, NK Popnikolov… - Gastroenterology, 2001 - Elsevier
Background & Aims: To assess the prevalence of flat and depressed (F&D) colorectal
adenomas in the United States, we performed a prospective study of 211 American patients …
adenomas in the United States, we performed a prospective study of 211 American patients …
Microsatellite instability status determined by next‐generation sequencing and compared with PD‐L1 and tumor mutational burden in 11,348 patients
A Vanderwalde, D Spetzler, N Xiao, Z Gatalica… - Cancer …, 2018 - Wiley Online Library
Microsatellite instability (MSI) testing identifies patients who may benefit from immune
checkpoint inhibitors. We developed an MSI assay that uses data from a commercially …
checkpoint inhibitors. We developed an MSI assay that uses data from a commercially …
[HTML][HTML] Activation of the hedgehog pathway in advanced prostate cancer
T Sheng, C Li, X Zhang, S Chi, N He, K Chen… - Molecular cancer, 2004 - Springer
Background The hedgehog pathway plays a critical role in the development of prostate.
However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer …
However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer …
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy
TR Hodges, M Ott, J Xiu, Z Gatalica, J Swensen… - Neuro …, 2017 - academic.oup.com
Background. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the
frequency of expression of potential predictive biomarkers is unknown in glioma. Methods. In …
frequency of expression of potential predictive biomarkers is unknown in glioma. Methods. In …
Respiratory syncytial virus–induced activation of nuclear factor–κB in the lung involves alveolar macrophages and toll-like receptor 4–dependent pathways
HA Haeberle, R Takizawa, A Casola… - The Journal of …, 2002 - academic.oup.com
The transcription factor nuclear factor (NF)–κB controls the expression of numerous
respiratory syncytial virus (RSV)–inducible inflammatory and immunomodulatory genes …
respiratory syncytial virus (RSV)–inducible inflammatory and immunomodulatory genes …