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CLINICAL AND PATHOLOGICAL FINDINGS IN OCHRONOSIS
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  1. Loyd R. Wagner,
  2. James L. Knott,
  3. Reginald A. Machaffie,
  4. John R. Walsh
  1. Veterans Administration Hospital, Omaha, Nebraska

    Abstract

    A case of ochronosis with far-advanced cardiovascular, skeletal, and prostatic manifestations is reported. An attempt is made to correlate the location of pigment with other pathological changes in this disorder. A brief discussion of the hereditary factors, the metabolic pathways of homogentisic acid, and the pathogenesis of ochronosis is presented.

    http://dx.doi.org/10.1136/jcp.13.1.22

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