The serum protein patterns of groups of Nigerians including 98 children partially protected by “daraprim” against malaria, and 113 unprotected children, have been studied.
The protected children have a significantly lower concentration of serum γ globulin than the unprotected children from the age of 12 months onwards.
In children, sicklers have a significantly higher serum γ globulin than non-sicklers.
It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.
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