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SYPHILITIC PAROXYSMAL COLD HAEMOGLOBINURIA
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  1. D. J. Parish,
  2. J. R. A. Mitchell
  1. Department of Pathology, University of Birmingham, Oxford
  2. Department of Haematology, Radcliffe Infirmary, Oxford

    CASE REPORT AND STUDY OF THE COOMBS TEST

    Abstract

    A case of congenital syphilis which presented with paroxysmal cold haemoglobinuria is described.

    The patient had aortic incompetence, and the significance of this finding is discussed.

    The Coombs test was studied, and positive results appear to be due to interaction between antiglobulin serum and complement adsorbed on to the test cells, this adsorption being promoted by the cold antibodies.

    http://dx.doi.org/10.1136/jcp.13.3.237

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      CASE REPORT AND STUDY OF THE COOMBS TEST