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The significance of Howell-Jolly bodies and giant metamyelocytes in marrow smears
  1. D. W. Dawson,
  2. H. P. R. Bury1
  1. Department of Pathology, Crumpsall Hospital, Manchester


    Howell-Jolly bodies in erythroid precursors can be found in the marrow in a variety of diseases. More than 1% in the later erythroblasts is rarely found except in vitamin B12 or folic acid deficiency states.

    Giant metamyelocytes are probably always the result of vitamin B12 or folic acid deficiency. A distinction is drawn between the deficiency of, and therapeutic need for, vitamin B12 and folic acid.

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    • 1 Present address: Children's Hospital, Sheffield, 10.