Article Text

Download PDFPDF

Changes in serum vitamin B12 levels in patients with megaloblastic anaemia treated with folic acid
  1. S. Johnson,
  2. S. P. Swaminathan,
  3. S. J. Baker
  1. Christian Medical College Hospital, Vellore, South India


    In 21 patients with megaloblastic anaemia associated with the tropical malabsorption syndrome serum vitamin B12 levels have been measured serially before and during parenteral folic acid therapy.

    In 11 patients there was a significant rise in serum B12 levels, reaching a peak three to 17 days after starting the folic acid. In three of these cases, absorption of labelled B12 was the same before and after the administration of folic acid. In two cases there was a fall in serum B12 levels and in seven there was no change. In one case small amounts of folic acid produced no change in serum B12 levels, whereas larger doses produced a prompt but transient rise.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.