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Fatal recurrence of parathyroid carcinoma after seven years
  1. J. P. Caley1,
  2. E. E. Jones,
  3. D. H. Collins
  1. Royal Infirmary, Sheffield
  2. Department of Pathology, University of Sheffield


    The case is reported of a woman who died at the age of 36 from parathyroid carcinoma. The removal, seven years earlier, of a large parathyroid tumour, judged at that time to be benign, was followed by a remission of symptoms for about four years after which they recurred. At necropsy, a well-differentiated parathyroid carcinoma showed local invasion and lymph-node metastases in the neck. Review of the original `adenoma' suggested that this growth might have been a carcinoma.

    The total number of recorded cases of hyperfunctioning parathyroid carcinoma is still limited but has now reached at least 37. Carcinoma is rarely to be diagnosed except at necropsy; nevertheless, it seems to be the important cause of delayed recurrence of symptoms after parathyroidectomy. The evolution of the growth is often very slow.

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    • 1 Present address: Mansfield General Hospital, Mansfield, Notts.