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An investigation into the use of activated and non-activated papain in routine rhesus blood grouping
  1. G. C. B. Winter1,
  2. B. E. Wratten
  1. R.A.F. Institute of Pathology and Tropical Medicine, Halton, Aylesbury, Bucks.


    The activities of three commercial products of papain were compared as supplied and after activation, and when used in the enzyme-serum method for rhesus (D) grouping. Certain dangers in activation became apparent, and accurate determination of the proportions of papain to anti-D appeared more important than indiscriminate activation without reference to the initial enzyme activity. A technique for assessing these proportions is described.

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    • 1 Present address: Department of Public Health, Tower Hill, Bristol 2.