Part II The mechanism of resistance 1
A study of the action of the culture filtrates of 10 strains of S. typhi resistant to chloramphenicol showed that two of the strains produced an extracellular substance which enabled a strain of S. typhi sensitive to chloramphenicol to grow in a mixture of the filtrate and the antibiotic. A study of the properties of this substance suggested that it was an enzyme.
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1 A paper read before the twelfth annual meeting of the Indian Association of Pathologists in 1961.