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A cytological and histological study of acute premyelocytic leukaemia
  1. Jean Bernard,
  2. J. Lasneret,
  3. J. Chome,
  4. J. P. Levy,
  5. M. Boiron
  1. Laboratory of Experimental Haematology, Research Institute for Blood Diseases, Hospital of Saint Louis, Paris


    Among the acute leukaemias of the granulocytic group, acute premyelocytic leukaemia is distinguished by the severity of its haemorrhages, the frequency of hypofibrinaemia, a rapidly fatal course, and an unusual cellular hyperplasia. Myelograms show an increased proportion (average 80%) of characteristic cells of large diameter, with numerous azurophil granules. The infiltration of other organs is inconstant.

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      BMJ Publishing Group Ltd and Association of Clinical Pathologists