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Significance of platelet antibodies in neonatal thrombocytopenic purpura affecting a pair of siblings
  1. K. L. G. Goldsmith,
  2. W. J. Jenkins,
  3. E. S. Mucklow,
  4. I. C. S. Normand
  1. M.R.C. Blood Group Reference Laboratory, London
  2. Regional Blood Transfusion Centre, Brentwood, Essex
  3. Paediatric Department, University College Hospital Medical School, London


    A pair of siblings, both of whom had neonatal thrombocytopenic purpura, are described. During the first pregnancy, the mother was given chlorothiazide and the implications of this therapy are considered. At the end of the second pregnancy a platelet iso-antibody was detected in the maternal serum. The possible reason for not detecting this antibody in the serum of the second child is considered.

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