Article Text

Download PDFPDF
Histochemical localization of copper in the gastrointestinal tract of the rat
  1. A. Olufemi Williams1
  1. Department of Pathology, Queen's University, Belfast


    Three histochemical reactions for the localization of copper were applied to liver and different parts of the gastrointestinal tract of normal as well as of rats poisoned with a solution of copper. Variable quantities of copper were demonstrated in the livers of all the poisoned rats and in 21 out of 24 sections of jejunum. Rubeanic acid counterstained with 0·5% Cresyl violet gave the best results. Copper was not demonstrable in the livers or the gastrointestinal tract of normal rats. As the metal was concentrated in the upper jejunum, it is likely that this is the site of absorption. Detection of this metal may assist in the diagnosis of hepatolenticular degeneration.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


    • 1 Present address: Department of Pathology, University of Ibadan, Ibadan, Nigeria.