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Coagulation studies in massive pulmonary haemorrhage of the newborn
  1. J. T. Roberts,
  2. A. J. Davies,
  3. A. L. Bloom
  1. Welsh National School of Medicine, Institute of Pathology, Royal Infirmary, Cardiff


    Coagulation studies were performed on two newborn infants with fatal massive pulmonary haemorrhage. The first showed a reduced level of plasma fibrinogen with defective thrombin-fibrinogen reaction, corrected by protamine, and defective thromboplastin generation. In the second case, a premature infant, the fibrinogen level was normal but there was a severe defect in thromboplastin generation with evidence of an inhibitor. A relationship between the pulmonary haemorrhage and coagulation defects is suggested but not established.

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