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Possible use of phosphohexose isomerase as a preliminary to exfoliative cytology in screening for cervical carcinoma
  1. Grainger G. Muir
  1. Department of Clinical Biochemistry, Luton and Dunstable and Bedford General Hospitals


    The activities of phosphohexose isomerase and 6-phosphogluconate dehydrogenase have been studied in the vaginal fluid of women from the gynaecological departments. Women from these departments gave a very high false positive rate, though no cases of carcinoma in situ were not detected by estimating phosphohexose isomerase levels. It gave considerably better results in malignancy than 6-phosphogluconate dehydrogenase. It is suggested that the use of phosphohexose isomerase might be of value in screening well women during a mass cytology programme.

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    • 1 This work is part of an M.D. thesis submitted to the University of London.