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Effect of age, sex, and diurnal variation on the human fibrinolytic system
  1. R. D. Mann
  1. Clinical Research Department, Pfizer Limited, Sandwich, Kent


    Fibrinolytic activity, as shown by the dilute blood clot lysis time, tends to show a diurnal variation, but is relatively unaffected by age and sex.

    Mean plasma anti-urokinase activity is consistently and significantly greater in females in the post-menstrual week than in age-matched males, but is relatively unaffected by daily variation and age. This sex difference in the activity of plasma, which is inhibitory to fibrinolysis, is of a degree which makes this measurement important in studies of the fibrinolytic system in healthy persons and disease states.

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