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Effect of diluents on blood clot lysis
  1. M. J. Gallimore
  1. Department of Biochemical Pharmacology, Pfizer Limited, Sandwich, Kent
  2. Therapeutics Research Division, Pfizer Limited, Sandwich, Kent


    One of the current methods used for measuring natural fibrinolytic activity in blood involves dilution of the blood with phosphate buffer. An adaptation of this method using a solution of sodium acetate as diluent is described. Evidence is given to show that dilute blood clots lyse not only because of the dissociation of an antiplasmin-plasmin complex, but also by virtue of a reduction of the intrinsic chloride ion concentration.

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