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Complete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles—beta thalassaemia
  1. A. J. Marengo-Rowe1,
  2. A. W. McCracken2,
  3. P. Flanagan
  1. Royal Air Force Institute of Pathology and Tropical Medicine, Halton, Aylesbury


    A family study is reported in which all three siblings were shown to be doubly heterozygous for haemoglobin D Los Angeles and beta thalassaemia, which resulted in a complete suppression of haemoglobin A synthesis. This demonstrates the effects of genetic interaction which occur when the genes for haemoglobin D Los Angeles and beta thalassaemia are both transmitted to the offspring. The importance of family studies in the investigation of haemoglobin abnormalities is stressed.

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    • 1 Present addresses: Royal Postgraduate Medical School, Du Cane Road, London, W.12.

    • 2 Department of Pathology, University of Texas Medical School at San Antonio, Texas, U.S.A.