Article Text

Download PDFPDF
Complete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles—beta thalassaemia
  1. A. J. Marengo-Rowe1,
  2. A. W. McCracken2,
  3. P. Flanagan
  1. Royal Air Force Institute of Pathology and Tropical Medicine, Halton, Aylesbury

    Abstract

    A family study is reported in which all three siblings were shown to be doubly heterozygous for haemoglobin D Los Angeles and beta thalassaemia, which resulted in a complete suppression of haemoglobin A synthesis. This demonstrates the effects of genetic interaction which occur when the genes for haemoglobin D Los Angeles and beta thalassaemia are both transmitted to the offspring. The importance of family studies in the investigation of haemoglobin abnormalities is stressed.

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Footnotes

    • 1 Present addresses: Royal Postgraduate Medical School, Du Cane Road, London, W.12.

    • 2 Department of Pathology, University of Texas Medical School at San Antonio, Texas, U.S.A.