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Cystinosis: electron microscopic evidence of lysosomal storage of cystine in lymph node
  1. A. D. Patrick,
  2. B. D. Lake
  1. Department of Chemical Pathology, Institute of Child Health, London
  2. Department of Morbid Anatomy, Institute of Child Health, London


    Electron microscopic examination of a biopsy specimen of cystinotic lymph node demonstrated that cystine crystals were entirely intracellular, and that the majority, including those of the largest size, were enclosed by intact limiting membranes. Acid phosphatase activity was localized specifically at the periphery of the crystal profiles and the smallest crystal aggregates were contained in osmophilic dense bodies which had the appearance of progressively swollen lysosomes. The implications of the suggested lysosomal distribution of cystine are discussed.

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