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Intravenous iron-dextran: studies on unsaturated iron-binding capacity
  1. J. S. G. Cox,
  2. G. F. Moss,
  3. I. Bremner1,
  4. Janet Reason
  1. Fisons Pharmaceuticals Limited, Holmes Chapel, Cheshire


    A method is described for measuring the plasma unsaturated iron-binding capacity in the presence of very high concentrations of iron as iron-dextran. The procedure utilizes 59Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column.

    The unsaturated iron-binding capacity has been measured in rabbits and dogs after intravenous injection of iron-dextran and in human subjects after total dose infusion of iron-dextran. No evidence of saturation of the unsaturated iron-binding capacity was found even when the plasma iron values were greater than 40,000 μg Fe/100 ml.

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    • 1 Present address: Nutritional Biochemistry Department, Rowett Research Institute, Bucksburn, Aberdeenshire.