Factor VIII and antibody levels in plasma fractions prepared by cryoprecipitation
Most of the antibody activity of plasma was found to remain in the supernatant fraction following the preparation of factor-VIII-rich cryoprecipitates. The low level of antibody remaining in these cryoprecipitates indicated that they could safely be used as a source of factor VIII for replacement therapy. Washing the cryoprecipitates farther reduced their antibody titres without materially affecting their factor VIII content.
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