Article Text

Download PDFPDF
Uncertainties in the determination of the `cortisol-binding capacity' of plasma and their removal
  1. C. W. Burke
  1. Department of Medicine, Royal Postgraduate Medical School, Ducane Road, London

    Abstract

    The determination of the `cortisol-binding capacity' by gel filtration of a small plasma sample at low temperature after the addition of cortisol results in an arbitrary measurement dependent upon experimental conditions. It is unsatisfactory also because it misleads as to conditions at 37°C. Steady-state gel filtration of cortisol in plasma can be done at 37°C, at which temperature it overcomes known variables in present methods. It should prove of clinical value in showing abnormalities of cortisol binding in disease.

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.