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Estimation of platelet adhesiveness on whole blood and platelet-rich plasma
  1. Sidney Shaw,
  2. Geoffrey D. Pegrum,
  3. Sylvia Wolff
  1. Department of Haematology, Charing Cross Hospital Medical School, London


    Platelet adhesive tests were carried out in parallel on whole blood and platelet-rich plasma. A column of glass microspherules was used and adenosine diphosphate (ADP) was added to the platelet-rich plasma before passage through the column.

    Preliminary observations were made to show the effect of the containers and the anticoagulant used. The influence on platelets when stored at 4°C and standing or mixing at room temperature was also assessed. The apparatus used to measure adhesiveness was designed to produce a constant rate of flow through a standard column of glass microspherules.

    Using both methods, adhesiveness was studied on 70 healthy blood donors. The result showed a significant correlation between the level of adhesiveness found with each technique.

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