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Measurement of plasma volume by means of 59Fe-labelled dextran and Evans blue compared
  1. R. J. Wilson,
  2. Ivor H. Mills1
  1. Department of Investigative Medicine and Addenbrooke's Hospital, Cambridge


    The apparent volumes of distribution of Evans blue and 59Fe-dextran were determined in 18 studies.

    59Fe-dextran volume was 5% lower than Evans blue volume, a highly significant difference.

    The rate of loss of 59Fe dextran from the circulation was significantly less than that of Evans blue.

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    • 1 Address requests for reprints to Professor Ivor H. Mills, Department of Investigative Medicine, Addenbrooke's Hospital, Trumpington Street, Cambridge, England.