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A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide
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  1. G. C. Jenkins,
  2. D. T. D. Hughes,
  3. P. C. Hall
  1. The London Hospital, London

    Abstract

    The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively inhibits dihydrofolate reductase in bacteria but not in man. Only minor effects on folate metabolism were observed in nine cases, causing no clinical concern. Some degree of thrombocytopenia occurred in the tenth case which improved when folinic acid was given.

    http://dx.doi.org/10.1136/jcp.23.5.392

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