Article Text

Download PDFPDF
Serum alpha2-macroglobulin, transferrin, albumin, and IgG levels in preeclampsia
  1. C. H. W. Horne,
  2. P. W. Howie,
  3. R. B. Goudie
  1. University Department of Pathology, Western Infirmary, Glasgow
  2. University Department of Obstetrics and Gynaecology, Western Infirmary, Glasgow


    A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls, but there are significant falls in α2-macroglobulin and IgG. When preeclampsia is accompanied by proteinuria there is a marked fall in albumin and an increase in α2-macroglobulin. Since α2-macroglobulin has antiplasmin activity it is possible that increased levels of this protein in preeclampsia accompanied by proteinuria contribute to the intravascular coagulation which has been described in this disorder.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.