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An assessment of techniques suitable for the diagnosis of sickle-cell disease and haemoglobin C disease in cord blood samples
  1. G. I. Yawson,
  2. R. G. Huntsman,
  3. J. S. Metters
  1. Department of Haematology, St Thomas' Hospital, London
  2. Department of Obstetrics, St Thomas' Hospital, London


    Agar gel, cellulose acetate, and starch gel electrophoresis are all capable of diagnosing sickle-cell anaemia, sickle-cell haemoglobin C disease, and haemoglobin C disease in cord blood samples. Of these three electrophoretic techniques, agar gel is the easiest to interpret.

    Paper electrophoresis can reliably and rapidly detect sickle haemoglobin and haemoglobin C in cord blood samples. Being incapable of differentiating foetal and normal adult haemoglobin, the value of paper electrophoresis is limited to an initial screening procedure.

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