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Vitamin B12 absorption in some neurological and neuroendocrine disorders
  1. D. Donaldson1,
  2. P. T. Lascelles
  1. Department of Chemical Pathology, The Institute of Neurology, The National Hospitals for Nervous Diseases, Queen Square, London


    An assessment of vitamin B12 absorption in neurological patients has been made by both serum and urine counting of 57Co cyanocobalamin during the conventional Schilling test. Although patients with pernicious anaemia, some with subacute combined degeneration of the cord, have been studied, emphasis in the discussion is placed on the significantly increased excretion of the radioactive vitamin in a group of patients with pituitary insufficiency. Results are also given for epileptic patients who have developed folate deficiency (as assessed by serum folate levels) coincidental with anticonvulsant therapy, as well as for some patients who have had neurological symptoms or signs following partial gastrectomy operations.

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    • 1 Present address; Chemical Pathology Department, Redhill General Hospital, Earlswood Common, Redhill, Surrey. Requests for reprints should be addressed to D.D. at this address.