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Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances
  1. David P. Casemore
  1. Department of Virology, Public Health Laboratory, Middlesbrough, Teesside


    The effect of 24 anti-amoebic and other chemotherapeutic compounds on six strains of hartmannellid amoebae was studied by tissue culture, agar diffusion, and liquid axenic culture.

    Of the recognized anti-amoebic compounds only one inhibited growth of the amoebae, which were remarkable for their resistance.

    Two compounds, hydroxystilbamidine isethionate and 5-fluorocytosine, showed some amoebicidal activity while some others were inhibitory.

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