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Effects of oestrogen and progestogen on serum levels of α2-macroglobulin, transferrin, albumin, and IgG
  1. C. H. W. Horne,
  2. Annette C. Mallinson,
  3. J. Ferguson,
  4. R. B. Goudie
  1. University Department of Pathology, Western Infirmary, Glasgow


    The levels of four serum proteins, assayed by a radial immunodiffusion technique, have been measured in healthy women who had been given either the oestrogen or progestogen component of a combined oral contraceptive preparation for three weeks. Raised α2-macroglobulin and transferrin levels were found after oestrogen treatment but albumin and IgG did not significantly alter. In the progestogen-treated group all four proteins remained unchanged. The four proteins have also been assayed at frequent intervals during the normal menstrual cycle. No evidence of cyclical variation was found.

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