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Spicular arrangement of amyloid in renal biopsy
  1. I. D. Ansell1,
  2. A. M. Joekes
  1. Department of Pathology, Institute of Urology and St Peter's Hospitals, London
  2. Department of Medicine, Institute of Urology and St Peter's Hospitals, London


    A spicular arrangement of amyloid on the epithelial aspect of the glomerular basement membrane has been seen to a variable degree in silver-stained sections of renal biopsies in eight of 38 patients with amyloidosis. Electron microscopical examination revealed a spectrum of appearances of the amyloid fibrils which would account for this finding. Only two of these eight patients had amyloidosis secondary to chronic infection, a much lower proportion than in the group as a whole. The possibility of confusion with membranous nephropathy is discussed with relevance to possible modes of treatment.

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    • 1 Present address: Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital Medical School, London W12.