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Haem biosynthesis studied in patients with rheumatoid arthritis
  1. S. V. Johansson,
  2. P. O. Strandberg
  1. Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden
  2. Department of Medicine, Karolinska Hospital, Stockholm, Sweden


    In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found.

    In iron-deficiency anaemia the excretion of both porphobilinogen and δ-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.

    A further study on the erythrocyte activity of δ-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.

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