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Haem biosynthesis studied in patients with rheumatoid arthritis
Abstract
In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found.
In iron-deficiency anaemia the excretion of both porphobilinogen and δ-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.
A further study on the erythrocyte activity of δ-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.