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Cross-reacting material in genetic variants of haemophilia B
  1. Dominique Meyer,
  2. Ethel Bidwell,
  3. Marie José Larrieu
  1. Coagulation Department, Institute de Pathologie Cellulaire, Hôpital Bicêtre, Paris, France
  2. Churchill Hospital, Oxford


    Cross-reacting factor IX material (CRM) was immunologically detected in the plasma of 38 normal individuals and 21 out of 22 haemophilia B patients using a rabbit antibody to factor IX. The same reacting material was detected in only nine of these patients using a human antibody. These results indicate that the plasma of the majority of haemophilia B patients contains a protein-lacking biological activity but having antigenic determinants in common with normal factor IX.

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