Article Text

Download PDFPDF

Clinical pharmacology of cephalexin administered by intravenous injection
  1. J. A. Davies,
  2. J. M. Holt
  1. Nuffield Department of Clinical Medicine, The Radcliffe Infirmary, Oxford


    Cephalexin IG was given by intravenous injection to eight normal volunteers, five patients with chronic renal failure, and three patients during a period of haemodialysis. In normal subjects there was a rapid fall in serum concentration and 80% of the administered dose was excreted in the urine within two hours. The mean serum half life was 1·1 hours (range 0·6-1·8 hours). Prior treatment with probenecid in two subjects led to a twofold increase in serum concentration two hours after injection. In the patients with chronic renal failure antimicrobial activity persisted for 24 hours and the half life ranged from 6·1 to 18·1 hours. Haemodialysis led to partial removal of cephalexin from the blood, but antimicrobial activity remained eight hours after injection at the end of the dialysis period. The serum half life in these patients was 5·1, 5·6, and 5·7 hours.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.