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Serum protein levels in primary biliary cirrhosis
  1. R. N. M. MacSween,
  2. C. H. W. Horne,
  3. Anne J. Moffat,
  4. Hazel M. Hughes
  1. University Departments of Pathology, Western and Royal Infirmaries, Baird Street, Glasgow
  2. Centre for Rheumatic Diseases, Baird Street, Glasgow


    Serum levels of albumin, transferrin, α2-macroglobulin, β1C/β1A, IgA, IgG, and IgM have been determined in 73 patients with primary biliary cirrhosis and in age- and sex-matched controls. A highly significant fall in albumin was demonstrated, and there were highly significant increases in α2-macroglobulin and all three immunoglobulin levels. Transferrin and β1/Cβ1A levels were unchanged. No significant correlations were found between the titre of antimitochondrial antibody, the duration of symptoms, and any of the serum proteins estimated. A highly significant positive correlation was present between serum albumin and transferrin levels in both patient and control groups.

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