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The fibrinolytic enzyme system in hypertension
  1. B. Bennett,
  2. D. Ogston,
  3. G. P. M. Crawford,
  4. A. S. Douglas
  1. Department of Medicine, University of Aberdeen


    Fibrinogen, fibrinogen-related antigen (FR-antigen), and components of the fibrinolytic enzyme system were measured in patients with essential hypertension, renal disease with and without hypertension, and normal subjects. Essential hypertension was associated with a decrease in plasminogen activator and an increase in FR-antigen. In renal disease these changes were accompanied by increases in plasminogen activation inhibitor, alpha2-macroglobulin, alpha1-antitrypsin, and fibrinogen.

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