Article Text

Download PDFPDF
Bactericidal activity of metronidazole against Bacteroides fragilis
  1. J. P. F. Whelan,
  2. J. H. Hale
  1. Research Laboratories, May and Baker Ltd, Dagenham
  2. Public Health Laboratory, Newcastle-upon-Tyne


    Metronidazole was found to be active against Bacteroides fragilis strains isolated from human lesions. The minimal inhibitory concentrations (MIC) were from 0·16 to 2·5 μg/ml and the minimal bactericidal concentrations (MBC) were from 0·16 to 2·5 μg/ml; usually the MIC and MBC figures were equivalent. These levels are easily attainable in the serum following normal therapeutic doses. The drug is not toxic and side effects are rare and it would therefore seem highly suitable for treating Bacteroides infections and also may be considered prophylactically in certain situations that are described.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.