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The effect of age on the fibrinolytic enzyme system
  1. P. J. Hamilton,
  2. Audrey A. Dawson,
  3. D. Ogston,
  4. A. S. Douglas
  1. Department of Medicine, University of Aberdeen
  2. Department of Pathology, University of Aberdeen


    Components of the fibrinolytic enzyme system, FR-antigen and fibrinogen, were measured in 20 healthy volunteers aged 20-40 years and in 61 elderly subjects aged 66-96 years. Plasminogen activator levels did not significantly differ between the 20-40 and 66-75 age groups, but were higher in those over 75. Plasminogen showed no change with age except for a fall in those over 75. Fibrinogen, FR-antigen, α1-antitrypsin, and α2-macroglobulin all rose with age, but the mean fibrinogen concentration fell in the very elderly.

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