Article Text

This article has a correction. Please see:

Download PDFPDF
Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection
  1. J. D. Anderson1,
  2. R. W. Lacey,
  3. E. L. Lewis,
  4. M. A. Sellin
  1. Department of Bacteriology, The Medical School, Bristol


    Co-trimoxazole was found to have a predominantly bacteriostatic effect upon 28 urinary isolates of Enterobacteriaceae in nutrient broth and was never bactericidal in artificially infected urine. The components of co-trimoxazole were tested individually and trimethoprim was found to be at least as effective as co-trimoxazole in nutrient broth and in urine. Trimethoprim alone produced some bactericidal effect in urine but this was antagonized by sulphamethoxazole.

    Laboratory tests for evaluating these drugs may give a misleading impression of their activity in vivo. Further clinical comparisons should therefore be made between trimethoprim and cotrimoxazole to determine when trimethoprim should be used in preference to the combination.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


    • 1 Present address: The Group Pathology Laboratories, The County Hospital, York, YO3 7PG.

    Linked Articles

    • Correction
      BMJ Publishing Group Ltd and Association of Clinical Pathologists