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A new antigen on the epithelial membrane: its immunoperoxidase localisation in normal and neoplastic tissue.
  1. E Heyderman,
  2. K Steele,
  3. M G Ormerod


    Using antisera raised against defatted human cream we have demonstrated a new antigen on the epithelial membrane. An indirect immunoperoxidase technique on routinely processed histological sections was used, and we describe results which show that this antigen has a widespread but highly selective distribution, being apparently localised to membranes that have a secretory function. The antigen is carried by a variety of adenocarcinomas, suggesting that its localisation may have a role in the diagnosis and differential diagnosis of malignant disease.

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