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Research Article
Gas-liquid chromatographic measurement of lignocaine in small samples of canine myocardium after enzymatic digestion.
  1. D W Holt,
  2. M Loizou,
  3. R K Wyse

    Abstract

    A method is described whereby lignocaine can be measured in small samples of canine myocardium. A proteolytic enzyme is used to digest the tissue, and the drug, together with an internal standard, is subsequently extracted into an organic solvent and measured by gas-liquid chromatography. The method is reproducible using tissue samples as small as 50 mg and appears to be suitable for the measurement of a number of drugs in small samples of tissue.

    https://doi.org/10.1136/jcp.32.3.225

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