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Assessment of a radioisotopic assay for vitamin B12 using an intrinsic factor preparation with R proteins blocked by vitamin B12 analogues
  1. Barbara Bain,
  2. GN Broom,
  3. Jackie Woodside,
  4. RA Litwinczuk,
  5. SN Wickramasinghe
  1. Department of Haematology, St Mary's Hospital and Medical School, Praed St, London W2 1PG


    A competitive protein binding radioassay kit for serum vitamin B12 has been assessed. Precision, linearity, sensitivity, and specificity have been found to be satisfactory. Falsely-normal assay results in patients with vitamin B12 deficiency have not been observed.

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