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Polycythaemia rubra vera and hairy cell leukaemia in the same patient: studies on the spleen
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  1. GJ Mufti,
  2. TJ Hamblin,
  3. FK Stevenson*,
  4. M Fitchett†
  1. Department of Haematology, Royal Victoria Hospital, Bournemouth
  2. * Regional Immunology Unit, Tenovus Research Laboratory, General Hospital, Southampton
  3. † Regional Cytogenetics Unit, General Hospital, Salisbury

    Abstract

    The first association of polycythaemia rubra vera (PRV) and hairy cell leukaemia (HCL) is reported. The secretion by spleen cells in short term culture of IfGλ to the exclusion κ demonstrated that despite aberrant surface marker studies the HCL was a monoclonal tumour of B cells. Chromosomal studies on splenic cells were not able to demonstrate the common clonal origin of the two tumours.

    http://dx.doi.org/10.1136/jcp.35.12.1312

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