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Intracellular immunoglobulin distribution of bone marrow plasma cells as a diagnostic aid for primary amyloidosis.
  1. C Thielemans,
  2. W Aelbrecht,
  3. D Verbeelen,
  4. G Somers,
  5. M De Waele,
  6. B Van Camp


    In order to classify the underlying disorder in four patients with biopsy-proven amyloidosis without overt monoclonal gammopathy, the cytoplasmic immunoglobulin (Ig) distribution of bone marrow plasma cells was evaluated using direct immunofluorescence microscopy. This procedure revealed the presence of a monoclonal proliferation of light chain containing plasma cells, and thus led to the diagnosis of immunoglobulin-related amyloidosis.

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