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Primary biliary cirrhosis: an increased incidence of extrahepatic malignancies?
  1. P R Mills,
  2. P Boyle,
  3. E M Quigley,
  4. G G Birnie,
  5. F Jarrett,
  6. G Watkinson,
  7. R N MacSween


    In a retrospective review of 85 patients with primary biliary cirrhosis (PBC), 10 (11.8%) were noted to have extrahepatic malignant neoplasm. In seven female patients the tumour developed within a mean of 3.5 yr after the clinical onset of PBC. This observed number of tumours, 3.5 times more common than the expected age-adjusted incidence, was statistically significant at the 0.5% level.

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