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Acidosis and severe megaloblastic anaemia
  1. IM Franklin*,
  2. PBA Kernoff,
  3. D Isherwood,
  4. J Leek,
  5. DB Morgan
  1. Department of Haematology, The General Infirmary, Leeds LS1 3EX
  2. University Department of Medicine, The General Infirmary, Leeds LS1 3EX
  3. University Department of Chemical Pathology, The General Infirmary, Leeds LS1 3EX


    Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed an acidosis. Neither anaemia per se nor the metabolic defects of vitamin B12 or folic acid deficiency are likely to cause clinically significant lactic acidosis or hyperlactataemia.

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    • * Present address: Department of Clinical Haematology, University College Hospital, Gower Street, London WC1E 6AU.

    • Present address: Academic Department of Haematology, Royal Free Hospital, London NW3 2QG.