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Intermediate filaments in smooth muscle tumours
  1. DJ Evans,
  2. IA Lampert,
  3. M Jacobs*
  1. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12
  2. * Department of Academic Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3


    Antisera to the intermediate filaments vimentin and desmin react with fixed paraffin embedded tissue. Benign uterine myomas contain both classes of filaments. Gastrointestinal “smooth muscle tumours” however often lack desmin even when they appear histologically benign. In the sarcomas examined vimentin was the only class of intermediate filament present. The diagnostic and histogenetic implications of these findings are discussed.

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